What the 2026 outline covers
The exam follows the PTCE content outline that took effect on January 6, 2026. It has four domains: Medications (35%), Patient Safety and Quality Assurance (23.75%), Order Entry and Processing (22.5%) and Federal Requirements (18.75%). The odd-looking quarter percentages are what you get from whole questions out of 80: the weights work out to 28, 19, 18 and 15 scored questions.
Calculations are not a domain of their own. The outline marks them on individual tasks, and those tasks appear in all four domains: dose and duration of therapy under Medications, controlled-substance and restricted-drug quantities under Federal Requirements, error checking under Patient Safety, and the days' supply, concentration and dilution work that makes up the first task of Order Entry and Processing.
What to study in each domain, and in what order, is the subject of the separate study guide, linked at the end of this page.